Publications and Doctoral Theses from CAIDE Study
Anttila T, Helkala EL, Viitanen M, Kåreholt I, Fratiglioni L, Winblad B, Soininen H, Tuomilehto J, Nissinen A, Kivipelto M. Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study.Link to an external websiteOpens in a new tab BMJ. 2004 ;329(7465):539.
Anttila T, Helkala EL, Kivipelto M, Hallikainen M, Alhainen K, Heinonen H, Mannermaa A, Tuomilehto J, Soininen H, Nissinen A. Midlife income, occupation, APOE status, and dementia: a population-based study.Link to an external websiteOpens in a new tab Neurology. 2002;59(6):887-93.
Eskelinen MH, Ngandu T, Tuomilehto J, Soininen H, Kivipelto M. Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study.Link to an external websiteOpens in a new tab J Alzheimers Dis. 2009;16(1):85-91.
Eskelinen MH, Ngandu T, Tuomilehto J, Soininen H, Kivipelto M. Midlife healthy-diet index and late-life dementia and Alzheimer's disease.Link to an external websiteOpens in a new tab Dement Geriatr Cogn Dis Extra. 2011;1(1):103-12.
Eskelinen MH, Ngandu T, Helkala EL, Tuomilehto J, Nissinen A, Soininen H, Kivipelto M. Fat intake at midlife and cognitive impairment later in life: a population-based CAIDE study.Link to an external websiteOpens in a new tab Int J Geriatr Psychiatry. 2008;23(7):741-7.
Hooshmand B, Solomon A, Kåreholt I, Leiviskä J, Rusanen M, Ahtiluoto S, Winblad B, Laatikainen T, Soininen H, Kivipelto M. Homocysteine and holotranscobalamin and the risk of Alzheimer disease: a longitudinal study.Link to an external websiteAvautuu uudessa välilehdessä Neurology. 2010;75(16):1408-14.
Hooshmand B, Solomon A, Kåreholt I, Rusanen M, Hänninen T, Leiviskä J, Winblad B, Laatikainen T, Soininen H, Kivipelto M. Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study. Link to an external websiteOpens in a new tabJ Intern Med. 2012;271(2):204-12.
Håkansson K, Rovio S, Helkala EL, Vilska AR, Winblad B, Soininen H, Nissinen A, Mohammed AH, Kivipelto M. Association between mid-life marital status and cognitive function in later life: population based cohort study. Link to an external websiteOpens in a new tabBMJ. 2009;339:b2462.
Kivipelto M, Helkala EL, Hänninen T, Laakso MP, Hallikainen M, Alhainen K, Soininen H, Tuomilehto J, Nissinen A. Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study. Link to an external websiteOpens in a new tabNeurology. 2001;56(12):1683-9.
Kivipelto M, Ngandu T, Fratiglioni L, Viitanen M, Kåreholt I, Winblad B, Helkala EL, Tuomilehto J, Soininen H, Nissinen A. Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease.Link to an external websiteOpens in a new tab Arch Neurol. 2005;62(10):1556-60.
Kivipelto M, Helkala EL, Laakso MP, Hänninen T, Hallikainen M, Alhainen K, Soininen H, Tuomilehto J, Nissinen A. Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study.Link to an external websiteOpens in a new tab BMJ. 2001;322(7300):1447-51.
Kivipelto M, Ngandu T, Laatikainen T, Winblad B, Soininen H, Tuomilehto J. Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study. Link to an external websiteOpens in a new tabLancet Neurol. 2006;5(9):735-41.
Kivipelto M, Rovio S, Ngandu T, Kåreholt I, Eskelinen M, Winblad B, Hachinski V, Cedazo-Minguez A, Soininen H, Tuomilehto J, Nissinen A. Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study. Link to an external websiteOpens in a new tabJ Cell Mol Med. 2008;12(6B):2762-71.
Kivipelto M, Helkala EL, Laakso MP, Hänninen T, Hallikainen M, Alhainen K, Iivonen S, Mannermaa A, Tuomilehto J, Nissinen A, Soininen H. Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease.Link to an external websiteOpens in a new tab Ann Intern Med. 2002;137(3):149-55.
Kulmala J, Solomon A, Kåreholt I, Ngandu T, Rantanen T, Laatikainen T, Soininen H, Tuomilehto J, Kivipelto M. Association between mid- to late life physical fitness and dementia: evidence from the CAIDE study.Link to an external websiteOpens in a new tab J Intern Med. 2014;276(3):296-307.
Laitinen MH, Ngandu T, Rovio S, Helkala EL, Uusitalo U, Viitanen M, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M. Fat intake at midlife and risk of dementia and Alzheimer's disease: a population-based study.Link to an external websiteOpens in a new tab Dement Geriatr Cogn Disord. 2006;22(1):99-107.
Mangialasche F, Solomon A, Kåreholt I, Hooshmand B, Cecchetti R, Fratiglioni L, Soininen H, Laatikainen T, Mecocci P, Kivipelto M. Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults. Link to an external websiteOpens in a new tabExp Gerontol. 2013;48(12):1428-35.
Ngandu T, von Strauss E, Helkala EL, Winblad B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M. Education and dementia: what lies behind the association? Link to an external websiteOpens in a new tabNeurology. 2007;69(14):1442-50.
Ngandu T, Helkala EL, Soininen H, Winblad B, Tuomilehto J, Nissinen A, Kivipelto M. Alcohol drinking and cognitive functions: findings from the Cardiovascular Risk Factors Aging and Dementia (CAIDE) StudyLink to an external websiteOpens in a new tab. Dement Geriatr Cogn Disord. 2007;23(3):140-9.
Neuvonen E, Rusanen M, Solomon A, Ngandu T, Laatikainen T, Soininen H, Kivipelto M, Tolppanen AM. Late-life cynical distrust, risk of incident dementia, and mortality in a population-based cohort.Link to an external websiteOpens in a new tab Neurology. 2014;82(24):2205-12.
Rovio S, Spulber G, Nieminen LJ, Niskanen E, Winblad B, Tuomilehto J, Nissinen A, Soininen H, Kivipelto M. The effect of midlife physical activity on structural brain changes in the elderly. Neurobiol Aging. Link to an external websiteAvautuu uudessa välilehdessä2010;31(11):1927-36.
Rovio S, Kåreholt I, Viitanen M, Winblad B, Tuomilehto J, Soininen H, Nissinen A, Kivipelto M. Work-related physical activity and the risk of dementia and Alzheimer's diseaseLink to an external websiteOpens in a new tab. Int J Geriatr Psychiatry. 2007;22(9):874-82.
Rovio S, Kåreholt I, Helkala EL, Viitanen M, Winblad B, Tuomilehto J, Soininen H, Nissinen A, Kivipelto M. Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease. Link to an external websiteOpens in a new tabLancet Neurol. 2005;4(11):705-11.
Rusanen M, Ngandu T, Laatikainen T, Tuomilehto J, Soininen H, Kivipelto M. Chronic obstructive pulmonary disease and asthma and the risk of mild cognitive impairment and dementia: a population based CAIDE study. Link to an external websiteOpens in a new tabCurr Alzheimer Res. 2013;10(5):549-55.
Rusanen M, Kivipelto M, Levälahti E, Laatikainen T, Tuomilehto J, Soininen H, Ngandu T. Heart Diseases and Long-Term Risk of Dementia and Alzheimer's Disease: A Population-Based CAIDE Study. Link to an external websiteOpens in a new tabJ Alzheimers Dis. 2014;42(1):183-91.
Rusanen M, Rovio S, Ngandu T, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M. Midlife smoking, apolipoprotein E and risk of dementia and Alzheimer's disease: a population-based cardiovascular risk factors, aging and dementia study.Link to an external websiteOpens in a new tab Dement Geriatr Cogn Disord. 2010;30(3):277-84.
Solomon A, Kåreholt I, Ngandu T, Wolozin B, Macdonald SW, Winblad B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M. Serum total cholesterol, statins and cognition in non-demented elderly.Link to an external websiteOpens in a new tab Neurobiol Aging. 2009;30(6):1006-9.
Solomon A, Kåreholt I, Ngandu T, Winblad B, Nissinen A, Tuomilehto J, Soininen H, Kivipelto M. Serum cholesterol changes after midlife and late-life cognition: twenty-one-year follow-up study.Link to an external websiteOpens in a new tab Neurology. 2007;68(10):751-6.
Tolppanen AM, Solomon A, Kulmala J, Kåreholt I, Ngandu T, Rusanen M, Laatikainen T, Soininen H, Kivipelto M. Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia.Link to an external websiteOpens in a new tab Alzheimers Dement. 2014 Apr 7. pii: S1552-5260(14)00034-X. doi: 10.1016/j.jalz.2014.01.008.
Tolppanen AM, Ngandu T, Kåreholt I, Laatikainen T, Rusanen M, Soininen H, Kivipelto M. Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort.Link to an external websiteOpens in a new tab J Alzheimers Dis. 2014;38(1):201-9.
Vuorinen M, Kåreholt I, Julkunen V, Spulber G, Niskanen E, Paajanen T, Soininen H, Kivipelto M, Solomon A. Changes in vascular factors 28 years from midlife and late-life cortical thickness.Link to an external websiteOpens in a new tab Neurobiol Aging. 2013;34(1):100-9.
Vuorinen M, Solomon A, Rovio S, Nieminen L, Kåreholt I, Tuomilehto J, Soininen H, Kivipelto M. Changes in vascular risk factors from midlife to late life and white matter lesions: a 20-year follow-up study.Link to an external websiteOpens in a new tab Dement Geriatr Cogn Disord. 2011;31(2):119-25.
Vuorinen M, Spulber G, Damangir S, Niskanen E, Ngandu T, Soininen H, Kivipelto M, Solomon A. Midlife CAIDE Dementia Risk Score and Dementia-Related Brain Changes up to 30 Years Later on Magnetic Resonance ImagingLink to an external websiteOpens in a new tab. J Alzheimers Dis. 2014 Sep 3.
Wallin K, Solomon A, Kåreholt I, Tuomilehto J, Soininen H, Kivipelto M. Midlife rheumatoid arthritis increases the risk of cognitive impairment two decades later: a population-based study.Link to an external websiteOpens in a new tab J Alzheimers Dis. 2012;31(3):669-76.
Mangialasche F, Solomon A, Kåreholt I, Hooshmand B, Cecchetti R, Fratiglioni L, Soininen H, Laatikainen T, Mecocci P, Kivipelto M. Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults.Link to an external websiteOpens in a new tab Exp Gerontol. 2013;48(12):1428-35.
Rusanen M, Ngandu T, Laatikainen T, Tuomilehto J, Soininen H, Kivipelto M. Chronic obstructive pulmonary disease and asthma and the risk of mild cognitive impairment and dementia: a population based CAIDE study.Link to an external websiteOpens in a new tab Curr Alzheimer Res. 2013;10(5):549-55.
Vuorinen M, Kåreholt I, Julkunen V, Spulber G, Niskanen E, Paajanen T, Soininen H, Kivipelto M, Solomon A. Changes in vascular factors 28 years from midlife and late-life cortical thickness. Neurobiol Aging. Link to an external websiteOpens in a new tab2013;34(1):100-9.
Kulmala J, Solomon A, Kåreholt I, Ngandu T, Rantanen T, Laatikainen T, Soininen H, Tuomilehto J, Kivipelto M. Association between mid- to late life physical fitness and dementia: evidence from the CAIDE study.Link to an external websiteOpens in a new tab J Intern Med. 2014;276(3):296-307.
Neuvonen E, Rusanen M, Solomon A, Ngandu T, Laatikainen T, Soininen H, Kivipelto M, Tolppanen AM. Late-life cynical distrust, risk of incident dementia, and mortality in a population-based cohort. Link to an external websiteOpens in a new tabNeurology. 2014;82(24):2205-12.
Rusanen M, Kivipelto M, Levälahti E, Laatikainen T, Tuomilehto J, Soininen H, Ngandu T. Heart Diseases and Long-Term Risk of Dementia and Alzheimer's Disease: A Population-Based CAIDE Study.Link to an external websiteOpens in a new tab J Alzheimers Dis. 2014;42(1):183-91.
Tolppanen AM, Ngandu T, Kåreholt I, Laatikainen T, Rusanen M, Soininen H, Kivipelto M. Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort.Link to an external websiteOpens in a new tab J Alzheimers Dis. 2014;38(1):201-9.
Tolppanen AM, Solomon A, Kulmala J, Kåreholt I, Ngandu T, Rusanen M, Laatikainen T, Soininen H, Kivipelto M. Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia.Link to an external websiteOpens in a new tab Alzheimers Dement. 2014 Apr 7.
Vuorinen M, Spulber G, Damangir S, Niskanen E, Ngandu T, Soininen H, Kivipelto M, Solomon A. Midlife CAIDE Dementia Risk Score and Dementia-Related Brain Changes up to 30 Years Later on Magnetic Resonance Imaging.Link to an external websiteOpens in a new tab J Alzheimers Dis. 2014 Sep 3.
Håkansson K, Soininen H, Winblad B, Kivipelto M. Feelings of Hopelessness in Midlife and Cognitive Health in Later Life: A Prospective Population-Based Cohort Study.Link to an external websiteOpens in a new tab PLoS One. 2015 Oct 13;10(10):e0140261.
Erratum in: PLoS One. 2015;10(11):e0142465. Link to an external websiteOpens in a new tab
Sindi S, Calov E, Fokkens J, Ngandu T, Soininen H, Tuomilehto J, Kivipelto M. The CAIDE Dementia Risk Score App: The development of an evidence-based mobile application to predict the risk of dementia. Link to an external websiteOpens in a new tabAlzheimers Dement (Amst) 2015 Jul 2;1(3):328-33.
Kivipelto M, Ngandu T. From Heart Health to Brain Health: Legacy of the North Karelia Project for Dementia Research.Link to an external websiteOpens in a new tab Glob Heart 2016 Jun;11(2):235-42.
Pekkala T, Hall A, Lötjönen J, Mattila J, Soininen H, Ngandu T, Laatikainen T, Kivipelto M, Solomon A. Development of a Late-Life Dementia Prediction Index with Supervised Machine Learning in the Population-Based CAIDE Study.Link to an external websiteOpens in a new tab J Alzheimers Dis 2016 Oct 14.
Sindi S, Hagman G, Håkansson K, Kulmala J, Nilsen C, Kåreholt I, Soininen H, Solomon A, Kivipelto M. Midlife Work-Related Stress Increases Dementia Risk in Later Life: The CAIDE 30-Year Study.Link to an external websiteOpens in a new tab J Gerontol B Psychol Sci Soc Sci 2016 Apr 8.
Sindi S, Kåreholt I, Solomon A, Hooshmand B, Soininen H, Kivipelto M. Midlife work-related stress is associated with late-life cognition.Link to an external websiteOpens in a new tab J Neurol. 2017 Sep;264(9):1996-2002.
Imtiaz B, Tolppanen AM, Solomon A, Soininen H, Kivipelto M. Estradiol and Cognition in the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) Cohort Study.Link to an external websiteOpens in a new tab J Alzheimers Dis. 2017;56(2):453-458.
Sindi S, Kåreholt I, Spulber G, Soininen H, Kivipelto M, Solomon A. Midlife Work-Related Stress is Associated with Late-Life Gray Matter Volume Atrophy.Link to an external websiteOpens in a new tab J Alzheimers Dis Rep. 2017 Dec 2;1(1):219-227.
Sindi S, Kåreholt I, Eskelinen M, Hooshmand B, Lehtisalo J, Soininen H, Ngandu T, Kivipelto M. Healthy Dietary Changes in Midlife Are Associated with Reduced Dementia Risk Later in Life.Link to an external websiteOpens in a new tab Nutrients. 2018 Nov 3;10(11):1649.
Sindi S, Johansson L, Skoog J, Mattsson AD, Sjöberg L, Wang HX, Fratiglioni L, Kulmala J, Soininen H, Solomon A, Johansson B, Skoog I, Kivipelto M, Kåreholt I. Sleep disturbances and later cognitive status: a multi-centre study.Link to an external websiteOpens in a new tab Sleep Med. 2018 Dec;52:26-33.
Hooshmand B, Rusanen M, Ngandu T, Leiviskä J, Sindi S, von Arnim CAF, Falkai P, Soininen H, Tuomilehto J, Kivipelto M. Serum Insulin and Cognitive Performance in Older Adults: A Longitudinal Study.Link to an external websiteOpens in a new tab Am J Med. 2019 Mar;132(3):367-373.
Liang Y, Ngandu T, Laatikainen T, Soininen H, Tuomilehto J, Kivipelto M, Qiu C. Cardiovascular health metrics from mid- to late-life and risk of dementia: A population-based cohort study in Finland.Link to an external websiteOpens in a new tab PLoS Med. 2020 Dec 15;17(12):e1003474.
Barbera M, Kulmala J, Lisko I, Pietilä E, Rosenberg A, Hallikainen I, Hallikainen M, Laatikainen T, Lehtisalo J, Neuvonen E, Rusanen M, Soininen H, Tuomilehto J, Ngandu T, Solomon A, Kivipelto M. Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+ study protocol.Link to an external websiteOpens in a new tab BMC Geriatr. 2020 Jul 10;20(1):238.
Neuvonen E, Hall A, Tolppanen AM, Ngandu T, Rusanen M, Laatikainen T, Soininen H, Kivipelto M, Solomon A. Late-life personality traits, cognitive impairment, and mortality in a population-based cohort.Link to an external websiteOpens in a new tab Int J Geriatr Psychiatry. 2020 Sep;35(9):989-999.
Sindi S, Darin-Mattsson A, Kåreholt I, Kulmala J, Ngandu T, Laatikainen T, Soininen H, Kivipelto M. Midlife improvements in financial situation are associated with a reduced dementia risk later in life: the CAIDE 30-year study.Link to an external websiteOpens in a new tab
Int Psychogeriatr. 2020 Nov;32(11):1317-1324.
Deckers K, Barbera M, Köhler S, Ngandu T, van Boxtel M, Rusanen M, Laatikainen T, Verhey F, Soininen H, Kivipelto M, Solomon A. Long-term dementia risk prediction by the LIBRA score: A 30-year follow-up of the CAIDE study.Link to an external websiteOpens in a new tab Int
J Geriatr Psychiatry. 2020 Feb;35(2):195-203.
Kulmala J, Tiilikainen E, Lisko I, Ngandu T, Kivipelto M, Solomon A. Personal Social Networks of Community-Dwelling Oldest Old During the Covid-19 Pandemic-A Qualitative StudyLink to an external websiteOpens in a new tab. Front Public Health. 2021 Dec 24;9:770965.
Tiilikainen E, Lisko I, Kekkonen E, Solomon A, Ngandu T, Kivipelto M, Kulmala J. Everyday Life Meaningfulness for the Community-Dwelling Oldest Old During the COVID-19 Pandemic.Link to an external websiteOpens in a new tab Front Psychol. 2021 Sep 9;12:716428.
Doctoral Theses from CAIDE Study
Elisa Neuvonen: The role of psychosocial factors in dementia prevention – From observational studies to a multidomain prevention trial. 2022.
http://urn.fi/URN:ISBN:978-952-61-4432-0Link to an external websiteOpens in a new tab
Timo Pekkala: Multimodal prediction of dementia and brain pathology. 2020.
http://urn.fi/URN:ISBN:978-952-61-3380-5Link to an external websiteOpens in a new tab
Miika Vuorinen: Cardiovascular Risk Factors and Dementia-related Structural Brain Changes on MRI: A 30-year follow-up study.Link to an external websiteOpens in a new tab 2014
Marjo Eskelinen: The effects of midlife diet on late-life cognition. Link to an external websiteOpens in a new tab2014.
Babak Hooshmand: The impact of homocysteine and B vitamins on Alzheimer’s disease, cognitive performance and structural brain changes.Link to an external websiteOpens in a new tab 2013.
Minna Rusanen: Smoking, pulmonary and heart diseases and the risk of cognitive impairment and dementia: an epidemiological approach.Link to an external websiteOpens in a new tab 2013.
Francesca Mangialasche: Exploring the role of vitamin E in Alzheimer's disease : an epidemiological and clinical perspective.Link to an external websiteOpens in a new tab 2012.
Alina Solomon: Cholesterol and late-life cognition. An epidemiological and clinical approach. Link to an external websiteOpens in a new tab2009.
Tiia Ngandu: Lifestyle-related risk factors in dementia and mild cognitive impairment: a population-based study.Link to an external websiteOpens in a new tab 2006.
Miia Kivipelto: Vascular risk factors in Alzheimer's disease and mild cognitive impairment: a longitudinal, population-based study.Link to an external websiteOpens in a new tab 2002.
