FINGER publications

  1. Richard E, Andrieu S, Solomon A, Mangialasche F, Ahtiluoto S, Moll van Charante EP, Coley N, Fratiglioni L, Neely AS, Vellas B, van Gool WA, Kivipelto M. Methodological challenges in designing dementia prevention trials - the European Dementia Prevention Initiative (EDPI). J Neurol Sci 2012;322:64-70.

  2. Kivipelto M, Solomon A, Ahtiluoto S, Ngandu T, Lehtisalo J, Antikainen R, Backman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Nissinen A, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): Study design and progress. Alzheimers Dement 2013;9:657-65.

  3. Ngandu T, Lehtisalo J, Levälahti E, Laatikainen T, Lindström J, Peltonen M, Solomon A, Ahtiluoto S, Antikainen R, Hänninen T, Jula A, Mangialasche F, Paajanen T, Pajala S, Rauramaa R, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. Recruitment and Baseline Characteristics of Participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)-A Randomized Controlled Lifestyle Trial.  Int J Environ Res Public Health 2014;11:9345-60.

  4. Ngandu T, Lehtisalo J, Solomon A, Levälahti E, Ahtiluoto S, Antikainen R, Bäckman L, Hänninen T, Jula A,  Laatikainen T, Lindström J, Mangialasche F, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet 2015;385:2255–2263.

  5. Kivipelto M, Ngandu T. From Heart Health to Brain Health: Legacy of the North Karelia Project for Dementia Research. Global Heart 2016;11:235-242.

  6. Kulmala J, Ngandu T, Pajala S, Lehtisalo J, Levälahti E, Antikainen R, Laatikainen T, Oksa H, Peltonen M, Rauramaa R, Soininen H, Strandberg T, Tuomilehto J, Kivipelto M. Leisure-Time and Occupational Physical Activity in Early and Late Adulthood in Relation to Later Life Physical Functioning. J Phys Act Health 2016;13:1079-1087.

  7. Lehtisalo J, Ngandu T, Valve P, Antikainen R, Laatikainen T, Strandberg T, Soininen H, Tuomilehto J, Kivipelto M, Lindström J. Nutrient intake and dietary changes during a 2-year multi-domain lifestyle intervention among older adults: secondary analysis of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) randomised controlled trial. Br J Nutr 2017;118:291-302.

  8. Pentikäinen H, Ngandu T, Liu Y, Savonen K, Komulainen P, Hallikainen M, Kivipelto M, Rauramaa R, Soininen H; FINGER Study Group. Cardiorespiratory fitness and brain volumes in men and women in the FINGER study. Age Aging 2017;46:310-313. 

  9. Sindi S, Ngandu T, Hovatta I, Kåreholt I, Antikainen R, Hänninen T, Levälahti E, Laatikainen T, Lindström J, Paajanen T, Peltonen M, Khalsa DS, Wolozin B, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M, Solomon A; FINGER study group. Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial. J Alzheimers Dis 2017;59:1459-1470.

  10. Strandberg TE, Levälahti E, Ngandu T, Solomon A, M Kivipelto, FINGER Study Group*. Health-Related Quality of Life in a Multidomain Intervention Trial to Prevent Cognitive Decline (FINGER). Eur Ger Med 2017;8:164–167.

  11. Kemppainen N, Johansson J, Teuho J, Parkkola , Joutsa J, Ngandu T, Solomon A, Stephen R, Liu Y, Hänninen T, Paajanen T, Laatikainen T, Soininen H, Jula A, Rokka J, Rissanen E, Vahlberg T, Peltoniemi J, Kivipelto M, Rinne JO. Brain Amyloid Load and Its Associations with Cognition and Vascular Risk Factors in FINGER Study. Neurology 2018;90(3):e206-e213. 

  12. Kivipelto M, Mangialasche F, Ngandu T; World Wide Fingers Network. World Wide Fingers will advance dementia prevention. Lancet Neurol 2018;17(1):27 (correspondence to:  Pointing the way to primary prevention of dementia. The Lancet Neurology, Vol. 16, No. 9, p677 (Editorial).

  13. Kivipelto M, Mangialasche F, Ngandu T. Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease. Nat Rev Neurol 2018;14(11):653-666.

  14. Kulmala J, Ngandu T, Kivipelto M. Prevention matters – time for global action and effective implementation. J Alzheimers Dis 2018;64(s1):S191-S198.

  15. Marengoni A, Rizzuto D, Fratiglioni L, Antikainen R, Laatikainen T, Lehtisalo J, Peltonen M, Soininen H, Strandberg T, Tuomilehto J, Kivipelto M, Ngandu T. The effect of a 2-year intervention consisting of diet, physical exercise, cognitive training, and monitoring of vascular risk on chronic morbidity—the FINGER randomised controlled trial. J Am Med Dir Assoc 2018;19:355-360.

  16. Rosenberg A, Ngandu T, Rusanen M, Antikainen R, Bäckman L, Havulinna S, Hänninen T, Laatikainen T, Lehtisalo J, Levälahti E, Lindström J, Paajanen T, Peltonen M, Soininen H, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Solomon A, Kivipelto M. Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: the FINGER trial. Alzheimers Dement 2018;14:263-270.

  17. Solomon A, Turunen H, Ngandu T, Peltonen M, Levälahti E, Helisalmi S, Antikainen R,  Bäckman L, Hänninen T, Jula A, Laatikainen T, Lehtisalo J, Lindström J, Paajanen T,  Pajala S, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial. JAMA Neurol 2018;75:462-470.

  18. Vaskivuo L, Hokkanen L, Hänninen T, Antikainen R, Bäckman L, Laatikainen T, Paajanen T, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M, Ngandu T. Associations between Prospective and Retrospective Subjective Memory Complaints and Neuropsychological Performance in Older Adults: The Finger Study. J Int Neuropsychol Soc 2018;24:1099-1109.

  19. Coley N, Ngandu T, Lehtisalo J, Soininen H, Vellas B, Richard E,  Kivipelto M, Andrieu S, for the HATICE, FINGER and MAPT/DSA groups. Adherence to multidomain interventions for dementia prevention: data from the FINGER and MAPT trials. Alzheimers Dement 2019;15:729-741.

  20. Kulmala J, Ngandu T, Havulinna S, Levälahti E, Lehtisalo J, Solomon A, Antikainen R, Laatikainen T, Pippola P, Peltonen M, Rauramaa R, Soininen H, Strandberg T, Tuomilehto J, Kivipelto M. The effect of multidomain lifestyle intervention on daily functioning in older people. J Am Geriatr Soc 2019;67(6):1138-1144. 

  21. Lehtisalo J, Levälahti E, Lindström J, Hänninen T, Paajanen T, Peltonen M, Antikainen R, Laatikainen T, Strandberg T, Soininen H, Tuomilehto J, Kivipelto M, Ngandu T. Dietary changes and cognition over 2 years within a multi-domain intervention trial – the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER). Alzheimers Dement 2019;15(3):410-417.

  22. Martikainen IK, Kemppainen N, Johansson J, Teuho J, Helin S, Liu Y, Helisalmi S, Soininen H, Parkkola R, Ngandu T, Kivipelto M, Rinne JO. Brain β-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline. Am J Neuroradiology 2019;40(1):80-85.

  23. Pentikäinen H, Savonen K, Ngandu T, Solomon A, Komulainen P, Paajanen T, Antikainen R, Kivipelto M, Soininen H, Rauramaa R. Cardiorespiratory fitness and cognition – longitudinal associations in the FINGER study. J Alzheimer Dis 2019;68(3):961-968.

  24. Stephen R, Liu Y, Ngandu T, Antikainen R, Hulkkonen J, Koikkalainen J, Kemppainen N, Lötjönen J, Levälahti E, Parkkola R, Pippola P, Rinne J, Strandberg T, Tuomilehto J, Vanninen R, Kivipelto M, Soininen H, Solomon A; FINGER study group. Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER). Alzheimers Res Ther 2019;11(1):53.

  25. Turunen M, Hokkanen L, Bäckman L, Stigsdotter-Neely A, Hänninen T, Paajanen T, Soininen H, Kivipelto M, Ngandu T. Computer-based cognitive training for older adults: Determinants of adherence. PLoS One 2019;14(7):e0219541.

  26. Vaskivuo L, Hokkanen L, Hänninen T, Antikainen R, Bäckman L, Laatikainen T, Paajanen T, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M, Ngandu T. Self and Informant Memory Reports in FINGER: Associations with Two-Year Cognitive Change. J Alzheimers Dis 2019;71(3):785-795.

  27. Kivipelto M, Mangialasche F, Snyder HM, ym. World-Wide FINGERS Network: A Global Approach to Risk Reduction and Prevention of Dementia. Alzheimers Dement 2020;16:1078-1094. 

  28. Kolehmainen L, Havulinna S, Ngandu T, Strandberg T, Levälahti E, Lehtisalo J, Antikainen R, Hietikko E, Peltonen M, Pölönen A, Soininen H, Tuomilehto J, Laatikainen T, Rauramaa R, Kivipelto M, Kulmala J. Earlier life leisure-time physical activity in relation to age-related frailty syndrome. Age Ageing 2020 Aug 17:afaa132. 

  29. Pekkala T, Hall A, Mangialasche F, Kemppainen N, Mecocci P, Ngandu T, Rinne JO, Soininen H, Tuomilehto J, Kivipelto M, Solomon A. Association of Peripheral Insulin Resistance and Other Markers of Type 2 Diabetes Mellitus with Brain Amyloid Deposition in Healthy Individuals at Risk of Dementia. J Alzheimers Dis 2020;76(4):1243-1248. 

  30. Pekkala T, Hall A, Ngandu T, van Gils M, Helisalmi S, Hänninen T, Kemppainen N, Liu Y, Lötjönen J, Paajanen T, Rinne JO, Soininen H, Kivipelto M, Solomon A. Detecting Amyloid Positivity in Elderly With Increased Risk of Cognitive Decline. Front Aging Neurosci 2020;12:228. 

  31. Rosenberg A, Mangialasche F, Ngandu T, Solomon A, Kivipelto M. Multidomain Interventions to Prevent Cognitive Impairment, Alzheimer's Disease, and Dementia: From FINGER to World-Wide FINGERS. J Prev Alzheimers Dis 2020;7(1):29-36. 

  32. Stephen R, Solomon A, Ngandu T, Levälahti E, Rinne JO, Kemppainen N, Parkkola R, Antikainen R, Strandberg T, Kivipelto M, Soininen H, Liu Y; FINGER study group. White Matter Changes on Diffusion Tensor Imaging in the FINGER Randomized Controlled Trial. J Alzheimers Dis 2020;78(1):75-86.  

  33. Deckers K, Köhler S, Ngandu T, Antikainen R, Laatikainen T, Soininen H, Strandberg T, Verhey F, Kivipelto M, Solomon A. Quantifying dementia prevention potential in the FINGER randomized controlled trial using the LIBRA prevention index. Alzheimers Dement 2021;17(7):1205-1212.

  34. Kulmala J, Rosenberg A, Ngandu T, Hemiö K, Tenkula T, Hyytiä A, Vienola M, Huhtamäki-Kuoppala M, Saarinen A, Korkki S, Laatikainen T, Solomon A, Kivipelto M. Facilitators and barriers to implementing lifestyle intervention programme to prevent cognitive decline. Eur J Public Health 2021;31(4):816-822.

  35. Lehtisalo J, Palmer K, Mangialasche F, Solomon A, Kivipelto M, Ngandu T. Changes in Lifestyle, Behaviors, and Risk Factors for Cognitive Impairment in Older Persons During the First Wave of the Coronavirus Disease 2019 Pandemic in Finland: Results From the FINGER Study. Front Psychiatry 2021;12:624125.

  36. Lisko I, Kulmala J, Annetorp M, Ngandu T, Mangialasche F, Kivipelto M. How can dementia and disability be prevented in older adults: where are we today and where are we going? J Intern Med 2021;289:807-830.

  37. Ngandu T, Lehtisalo J, Korkki S, Solomon A, Coley N, Antikainen R, Bäckman L, Hänninen T, Lindström J, Laatikainen T, Paajanen T, Havulinna S, Peltonen M, Neely AS, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER). Alzheimers Dement 2021 Oct 20.

  38. Sandebring-Matton A, Goikolea J, Björkhem I, Paternain L, Kemppainen N, Laatikainen T, Ngandu T, Rinne J, Soininen H, Cedazo-Minguez A, Solomon A, Kivipelto M. 27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial. Alzheimers Res Ther 2021;13(1):56. 

  39. Sindi S, Kåreholt I, Ngandu T, Rosenberg A, Kulmala J, Johansson L, Wetterberg H, Skoog J, Sjöberg L, Wang HX, Fratiglioni L, Skoog I, Kivipelto M. Sex differences in dementia and response to a lifestyle intervention: Evidence from Nordic population-based studies and a prevention trial. Alzheimers Dement 2021;17(7):1166-1178.

  40. Sindi S, Solomon A, Kåreholt I, Hovatta I, Antikainen R, Hänninen T, Levälahti E, Laatikainen T, Lehtisalo J, Lindström J, Paajanen T, Peltonen M, Singh Khalsa D, Wolozin B, Strandberg T, Tuomilehto J, Soininen H, Ngandu T, Kivipelto M; FINGER Study Group. Telomere Length Change in a Multidomain Lifestyle Intervention to Prevent Cognitive Decline: A Randomized Clinical Trial. J Gerontol A Biol Sci Med Sci 2021;76(3):491-498.

  41. Stephen R, Ngandu T, Liu Y, Peltonen M, Antikainen R, Kemppainen N, Laatikainen T, Lötjönen J, Rinne J, Strandberg T, Tuomilehto J, Vanninen R, Soininen H, Kivipelto M, Solomon A; FINGER Study Group. Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial: Results of a Post-Hoc Subgroup Analysis. J Gerontol A Biol Sci Med Sci 2021;76(8):1407-1414. 

  42. Solomon A, Handels R, Wimo A, Antikainen R, Laatikainen T, Levälahti E, Peltonen M, Soininen H, Strandberg T, Tuomilehto J, Kivipelto M, Ngandu T. Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk. J Alzheimers Dis 2021;82(4):1461-1466.

  43. Solomon A, Stephen R, Altomare D, Carrera E, Frisoni GB, Kulmala J, Molinuevo JL, Nilsson P, Ngandu T, Ribaldi F, Vellas B, Scheltens P, Kivipelto M; European Task Force for Brain Health Services. Multidomain interventions: state-of-the-art and future directions for protocols to implement precision dementia risk reduction. A user manual for Brain Health Services-part 4 of 6. Alzheimers Res Ther 2021 Oct 11;13:171.

  44. Alenius M, Hokkanen L, Koskinen S, Hallikainen I, Hänninen T, Karrasch M, Raivio MM, Laakkonen ML, Krüger J, Suhonen NM, Kivipelto M, Ngandu T. Cognitive Performance at Time of AD Diagnosis: A Clinically Augmented Register-Based Study. Front Psychol 2022;13:901945. 

  45. Alenius M, Ngandu T, Koskinen S, Hallikainen I, Hänninen T, Karrasch M, Kivipelto M, Raivio MM, Laakkonen ML, Krüger J, Suhonen NM, Hokkanen L. Education-Based Cutoffs for Cognitive Screening of Alzheimer's Disease. Dement Geriatr Cogn Disord 2022;51:42-55.

  46. Dehghan A, Pinto RC, Karaman I, Huang J, Durainayagam BR, Ghanbari M, Nazeer A, Zhong Q, Liggi S, Whiley L, Mustafa R, Kivipelto M, Solomon A, Ngandu T, Kanekiyo T, Aikawa T, Radulescu CI, Barnes SJ, Graça G, Chekmeneva E, Camuzeaux S, Lewis MR, Kaluarachchi MR, Ikram MA, Holmes E, Tzoulaki I, Matthews PM, Griffin JL, Elliott P. Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer's disease. Proc Natl Acad Sci U S A 2022;119(43):e2206083119.

  47. Goikolea J, Gerenu G, Daniilidou M, Mangialasche F, Mecocci P, Ngandu T, Rinne J, Solomon A, Kivipelto M, Cedazo-Minguez A, Sandebring-Matton A, Maioli S. Serum Thioredoxin-80 is associated with age, ApoE4, and neuropathological biomarkers in Alzheimer's disease: a potential early sign of AD. Alzheimers Res Ther 2022;14(1):37. 

  48. Janssen N, Handels RL, Wimo A, Antikainen R, Laatikainen T, Soininen H, Strandberg T, Tuomilehto J, Kivipelto M, Evers SMAA, Verhey FRJ, Ngandu T. Association Between Cognition, Health Related Quality of Life, and Costs in a Population at Risk for Cognitive Decline. J Alzheimers Dis 2022;89:623-632.

  49. Lehtisalo J, Rusanen M, Solomon A, Antikainen R, Laatikainen T, Peltonen M, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M, Ngandu T. Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial. Eur Heart J 2022 Jan 20:ehab922.

  50. Neuvonen E, Lehtisalo J, Ngandu T, Levälahti E, Antikainen R, Hänninen T, Laatikainen T, Lindström J, Paajanen T, Soininen H, Strandberg T, Tuomilehto J, Kivipelto M, Solomon A. Associations of Depressive Symptoms and Cognition in the FINGER Trial: A Secondary Analysis of a Randomised Clinical Trial. J Clin Med 2022;11:1449.

  51. Neuvonen E, Lehtisalo J, Solomon A, Antikainen R, Havulinna S, Hänninen T, Laatikainen T, Lindström J, Rautio N, Soininen H, Strandberg T, Tuomilehto J, Kivipelto M, Ngandu T. Psychosocial determinants for adherence to a healthy lifestyle and intervention participation in the FINGER trial: an exploratory analysis of a randomised clinical trial. Aging Clin Exp Res 2022;34:1793-1805. 

  52. Ngandu T, Lehtisalo J, Korkki S, Solomon A, Coley N, Antikainen R, Bäckman L, Hänninen T, Lindström J, Laatikainen T, Paajanen T, Havulinna S, Peltonen M, Neely AS, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER). Alzheimers Dement 2022;18:1325-1334.

  53. Rydström A, Darin-Mattsson A, Kåreholt I, Ngandu T, Lehtisalo J, Solomon A, Antikainen R, Bäckman L, Hänninen T, Laatikainen T, Levälahti E, Lindström J, Paajanen T, Havulinna S, Peltonen M, Sindi S, Soininen H, Neely AS, Strandberg T, Tuomilehto J, Kivipelto M, Mangialasche F. Occupational complexity and cognition in the FINGER multidomain intervention trial. Alzheimers Dement 2022;18(12):2438-2447.

  54. Röhr S, Kivipelto M, Mangialasche F, Ngandu T, Riedel-Heller SG. Multidomain interventions for risk reduction and prevention of cognitive decline and dementia: current developments. Curr Opin Psychiatry 2022 Jul 1;35:285-292. 

  55. Wimo A, Handels R, Antikainen R, Eriksdotter M, Jönsson L, Knapp M, Kulmala J, Laatikainen T, Lehtisalo J, Peltonen M, Sköldunger A, Soininen H, Solomon A, Strandberg T, Tuomilehto J, Ngandu T, Kivipelto M. Dementia prevention: The potential long-term cost-effectiveness of the FINGER prevention program. Alzheimers Dement 2022 Jul 16. 

  56. Norgren J, Sindi S, Sandebring-Matton A, Ngandu T, Kivipelto M, Kåreholt I. The Dietary Carbohydrate/Fat-Ratio and Cognitive Performance: Panel Analyses in Older Adults at Risk for Dementia. Curr Dev Nut. 2023;7:100096.

  57. Rydström A, Stephen R, Kåreholt I, Darin Mattsson A, Ngandu T, Lehtisalo J, Bäckman L, Kemppainen N, Rinne J, Sindi S, Soininen H, Vanninen R, Solomon A, Mangialasche F. The role of brain integrity in the association between occupational complexity and cognitive performance in subjects with increased risk of dementia. Gerontology 2023 Apr 18.

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