Tutkimukset ja julkaisut
Tutkimukset
Hanke tuottaa yhteistyötahojen sisäiseen käyttöön perustietoa raskauden aikaisen lääkkeiden käytön määrästä ja laadusta sekä vaikutuksista raskauden kulkuun, sikiön ja syntyneen lapsen terveyteen. Lisäksi hankkeessa on meneillään raskaudenaikaisten pitkäaikaissairauksien ja niihin liittyvän lääkehoidon vaikutuksiin kohdistuvia erillistutkimuksia. Osa erillistutkimuksista on kansallisia tai kansainvälisiä yhteistyötutkimuksia.
Raskausajan diabetes
Tilastotietoa synnyttäjistä, diabeteksen esiintyvyydestä ja diabeteksen lääkehoidosta raskausaikana koko maassa 2004–2018.
Julkaisut
2024
Cohen JM, Alvestad S, Suarez EA, Schaffer A, Selmer RM, Havard A, Bateman BT, Cesta CE, Zoega H, Odsbu I, Huybrechts KF, Kjerpeseth LJ, Straub L, Leinonen MK, Bjørk M, Nørgaard M, Gissler M, Ulrichsen SP, Hernandez-Diaz S, Tomson T, Furu K. Comparative risk of major congenital malformations with antiseizure medication combinations vs valproate monotherapy in pregnancy. Neurology 2024; 102(2):e207996.
2023
Cesta CE, Rotem R, Bateman BT, Chodick G, Cohen JM, Furu K, Gissler M, Huybrechts KF, Kjerpeseth LJ, Leinonen MK, Pazzagli L, Zoega H, Seely EW, Patorno E, Hernandez-Diaz S. Safety of GLP-1 receptor agonists and other second-line antidiabetics in early pregnancy. JAMA Internal Medicine 2023. Dec 11. doi: 10.1001/jamainternmed.2023.6663. Online ahead of print.
Kjerpeseth LJ, Cesta CE, Furu K, Engeland A, Gissler M, Gulseth HL, Karlstad Ø, Kieler H, Leinonen MK, Nørgaard M, Pazzagli L, Selmer R, Ulrichsen SP, Zoega H, Cohen JM. Metformin versus insulin and risk of major congenital malformations in pregnancies with type 2 diabetes - A Nordic register-based cohort study. Diabetes Care 2023; 46(8): 1556-1564.
Raitio A, Heiskanen S, Syvänen J, Leinonen MK, Kemppainen T, Löyttyniemi E, Ahonen M, Gissler M, Helenius I. Maternal Risk Factors for Congenital Vertebral Anomalies. A population-based study. J Bone Joint Surg Am 2023; 105(14): 1087-1092.
Dreier JW, Bjørk MH, Alvestad S, Gissler M, Igland J, Leinonen MK, Sun Y, Zoega H, Cohen JM, Furu K, Tomson T, Christensen J. Prenatal exposure to antiseizure medication and incidence of childhood- and adolescence onset psychiatric disorders: A Nordic population-based cohort study in children of mothers with epilepsy. JAMA Neurol 2023; 80(6): 568-577.
Huybrechts KF, Straub L, Karlsson P, Pazzagli L, Furu K, Gissler M, Hernandez-Diaz S, Nørgaard M, Zoega H, Bateman BT, Cesta CE, Cohen JM, Leinonen MK, Reutfors J, Selmer RM, Suarez EA, Ulrichsen SP, Kieler H. Association of in utero antipsychotic medication exposure with risk of congenital malformations in Nordic countries and the US. JAMA Psychiatry 2023; 80(2): 156-166.
Cohen JM, Alvestad S, Cesta CE, Bjørk M, Leinonen MK, Nørgaard M, Einarsdóttir K, Engeland A, Gissler M, Karlstad Ø, Klungsøyr K, Odsbu I, Reutfors J, Selmer R, Tomson T, Ulrichsen SP, Zoega H, Furu K. Comparative safety of antiseizure medication monotherapy for major malformations. Ann Neurol 2023; 93(3): 551-562.
2022
Vegrim HM, Dreier JW, Alvestad S, Gilhus NE, Gissler M, Igland J, Leinonen MK, Tomson T, Sun Y, Zoega H, Christensen J, Bjørk MH. Cancer risk in children of mothers with epilepsy and high-dose folic acid use during pregnancy. JAMA Neurol 2022; 79(11):1-10.
Turunen S, Vääräsmäki M, Marttila R, Leinonen MK, Gissler M, Männistö T, Suvanto E. Indications for intensive care unit treatment among neonates born to mothers with thyroid disease: A population-based cohort study. Acta Obstet Gynecol Scand 2022; 101(10): 1093-1101.
Alvestad S, Husebye ESN, Christensen J, Dreier JW, Sun Y, Igland J, Leinonen MK, Gissler M, Gilhus NE, Tomson T, Bjørk M. Folic acid and risk of preterm birth, preeclampsia and fetal growth restriction among women with epilepsy: A prospective cohort study. Neurology 2022; 99(6): e605-e615.
Bjørk M, Zoega H, Leinonen MK, Cohen JM, Dreier JW, Furu K, Gilhus NE, Gissler M, Halfdanarson O, Igland J, Sun Y, Tomson T, Alvestad S, Christensen J. Association of Prenatal Exposure to Antiseizure Medication with Risk of Autism and Intellectual Disability JAMA Neurol 2022; 79(7): 672-681.
Kong L, Chen X, Liang Y, Forsell Y, Gissler M, Lavebratt C. Associations of preeclampsia and perinatal complications with offspring neurodevelopmental and psychiatric disorders. JAMA Netw Open 2022; 5(1):e2145719.
Thurin NH, Pajouheshnia R, Roberto G, Dodd C, Hyeraci G, Bartolini C, Paoletti O, Nordeng H, Wallach-Kildemoes H, Ehrenstein V, Dudukina E, MacDonald T, De Paoli G, Loane M, Damase-Michel C, Beau AB, Droz-Perroteau C, Lassalle R, Bergman J, Swart K, Schink T, Cavero-Carbonell C, Barrachina-Bonet L, Gomez-Lumbreras A, Giner-Soriano M, Aragón M, Neville AJ, Puccini A, Pierini A, Ientile V, Trifirò G, Rissmann A, Leinonen MK, Martikainen V, Jordan S, Thayer D, Scanlon I, Georgiou ME, Cunnington M, Swertz M, Sturkenboom M, Gini R. From inception to ConcePTION: genesis of a network to support better monitoring and communication of medicines safety during pregnancy & breastfeeding. Clin Pharmacol Ther 2022; 111(1):321-331.
Halfdanarson O, Cohen JM, Karlstad Ø, Cesta CE, Bjørk MH, Håberg SE, Einarsdóttir K, Furu K, Gissler M, Hjellvik V, Kieler H, Leinonen MK, Mette Nørgaard M, Essen BÖ, Ulrichsen SP, Reutfors J, Zoega H. Antipsychotic use in pregnancy and risk of attention/deficit-hyperactivity disorder and autism spectrum disorder: A Nordic cohort study and sibling analysis. Evid Based Ment Health 2022; 25(2): 54-62.
Hjorth S, Pottegaard A, Broe A, Hemmingsen CH, Leinonen MK, Hargreave M, Nörby U, Nordeng H. Prenatal exposure to nitrofurantoin and risk of childhood leukaemia - a registry-based cohort study in four Nordic countries. Int J Epidemiol 2022; 51(3): 778-788.
2021
Seppälä LK, Madanat-Harjuoja LM, Leinonen MK, Lääperi M, Vettenranta K. Maternal thyroid disease and the risk of childhood cancer in the offspring. Cancers 2021; 13: 5409.
Cohen JM, Cesta CE, Kjerpeseth L, Leinonen MK, Halfdanarson O, Karlstad Ø, Karlsson P, Andersen M, Furu K, Hjellvik V. A Common Data Model for Harmonization in the Nordic Pregnancy Drug Safety Studies (NorPreSS)” Norsk Epidemiologi 2021; 29: 117-123.
Pakkasjärvi N, Syvänen J, Tauriainen A, Hyvärinen A, Sankilampi U, Leinonen MK, Gissler M, Helenius I, Raitio A. Prune Belly Syndrome in Finland – A population-based study on current epidemiology and hospital admissions. J Pediatr Urol 2021; 17(5):702.e1-702.e6.
Hjorth S, Hemmingsen CH, Benevent J, Broe A, Pottegaard A, Mørch L, Leinonen MK, Kjaer SK, Hargreave M, Nordeng H. Maternal Medication Use and Childhood Cancer in Offspring – Systematic Review and Considerations for Researchers. Am J Epidemiol 2021; 190(11): 2487-2499.
Ellfolk M, Leinonen MK, Gissler M, Kiuru-Kuhlefelt S, Saastamoinen L, Malm H. Second-generation antipsychotic use during pregnancy and risk of congenital malformations. Eur J Clin Pharmacol 2021; 77(11): 1737-1745.
Turunen S, Vääräsmäki M, Leinonen M, Gissler M, Männistö T, Suvanto E. The increased trend of levothyroxine treatment during pregnancy: a 13-year national study. Eur Thyroid 2021; 10(3): 230-236.
Seppälä LK, Madanat-Harjuoja LM, Troisi R, Sampson JN, Leinonen MK, Vettenranta K. Maternal autoimmune disease and risk of childhood cancer in the offspring: A Finnish registry-based study. Acta Pediatr 2021; 110(7):2259-2266.
Seppälä LK, Vettenranta K, Leinonen MK, Tommiska V, Madanat-Harjuoja LM. Preterm birth, neonatal therapies and the risk of childhood cancer. Int J Cancer 2021; 148(9): 2139-2147.
Raitio A, Tauriainen A, Leinonen MK, Syvänen J, Kemppainen T, Löyttyniemi E, Sankilampi U, Gissler M, Hyvärinen A, Helenius I. Extended spectrum penicillins reduce the risk of omphalocele -A population-based case-control study. J Pediatr Surg 2021; 56(9): 1590-1595.
2020
Turunen S, Vääräsmäki M, Lahesmaa-Korpinen AM, Leinonen MK, Gissler M, Männistö T, Suvanto E. Maternal hyperthyroidism and pregnancy outcomes: A population-based cohort study. Clin Endocrinol (Oxf) 2020; 93(6):721-728.
Bröms G, Kieler H, Ekbom A, Gissler M, Hellgren K, Leinonen MK, Pedersen L, Schmitt-Egenolf M, Sørensen HT, Granath F. Pediatric infections in the first three years of life after maternal anti-TNF treatment during pregnancy. Aliment Pharmacol Ther 2020; 52(5): 843-854.
Cohen JM, Cesta CE, Furu K, Einarsdóttir K, Gissler M, Havard A, Hernandez-Diaz S, Huybrechts KF, Kieler H, Leinonen MK, Li J, Reutfors J, Schaffer A, Selmer R, Yu Y, Zoega H, Karlstad Ø. Prevalence trends and individual patterns of antiepileptic drug use in pregnancy 2006-2016: A study in the five Nordic countries, United States and Australia. Pharmacoepidemiol Drug Saf 2020; 29(8):913-922.
Raitio A, Tauriainen A, Leinonen MK, Syvänen J, Kemppainen T, Löyttyniemi E, Sankilampi U, Gissler M, Hyvärinen A, Helenius I. Maternal risk factors for gastroschisis: a population-based case-control study. Birth Defects Res 2020; 112(13):989-995.
Raitio A, Lahtinen A, Syvänen J, Kemppainen T, Löyttyniemi E, Gissler M, Hyvärinen A, Helenius I. Gastroschisis in Finland 1993 to 2014-Increasing Prevalence, High Rates of Abortion, and Survival : A Population-Based Study. Eur J Pediatric Surg 2020; 30(6):536-540.
Reutfors J, Cesta CE, Cohen JM, Bateman BT, Brauer R, Einarsdóttir K, Engeland A, Furu K, Gissler M, Havard A, Hernandez-Diaz S, Huybrechts KF, Karlstad Ø, Leinonen MK, Li J, Man KCK, Pazzagli L, Schaffer A, Schink T, Wang Z, Yu Y, Zoega H, Bröms G. Antipsychotic drug use in pregnancy: a multinational study from ten countries. Schizophr Res 2020 Jun; 220:106-115.
Bröms G, Kieler H, Ekbom A, Gissler M, Hellgren K, Lahesmaa-Korpinen AM, Pedersen L, Schmitt-Egenolf M, Sørensen HT, Granath F. Anti-TNF treatment during pregnancy and birth outcomes: A population-based study from Denmark, Finland, and Sweden. Pharmacoepidemiol Drug Saf 2020; 29(3):316-327.
Kong L, Nilsson IAK, Brismar K, Gissler M, Lavebratt C. Associations of different types of maternal diabetes and body mass index with offspring psychiatric disorders. JAMA Netw Open 2020; 3(2):e1920787.
Ellfolk M, Tornio A, Niemi M, Leinonen MK, Lahesmaa-Korpinen AM, Malm H. Placental transporter-mediated drug interactions and offspring congenital anomalies. Br J Clin Pharmacol 2020; 86:868-879.
Ellfolk M, Leinonen MK, Gissler M, Lahesmaa-Korpinen AM, Saastamoinen L, Nurminen ML, et al. Second-generation antipsychotics and pregnancy complications. Eur J Clin Pharmacol 2020; 76(1):107-115.
Seppälä LK, Vettenranta K, Pitkäniemi J, Hirvonen E, Leinonen MK, Madanat-Harjuoja LM. Maternal Diabetes and Risk of Childhood Cancer in the Offspring. Int J Cancer 2020; 147: 662-668.
2019
Lavebratt C, Yang LL, Giacobini MB, Forsell Y, Schalling M, Partonen T, Gissler M. Early exposure to antibiotic drugs and risk for psychiatric disorders: a population-based study in Finland. Transl Psychiatry 2019 Nov 26; 9(1):317.
Cesta CE, Cohen JM, Pazzagli L, Bateman BT, Bröms G, Einarsdóttir K, Furu K, Havard A, Heino A, Hernandez-Diaz S, Huybrechts KF, Karlstad Ø, Kieler H, Li J, Leinonen MK, Løvdal Gulseth H, Tran D, Yu Y, Zoega H, Odsbu I. Antidiabetic Medication Use during Pregnancy: An International Utilization Study. BMJ Open Diabetes Res Care 2019; 7 (1): e000759.
Turunen S, Vääräsmäki M, Männistö T, Hartikainen AL, Lahesmaa-Korpinen AM, Gissler M, Suvanto E. Pregnancy and perinatal outcome among hypothyroid mothers: a population based cohort study. Thyroid 2019 Jan; 29(1):135-141.
Kong L, Nilsson IAK, Gissler M, Lavebratt C. Associations of maternal diabetes and body mass index with offspring birth weight and prematurity. JAMA Pediatr 2019; Apr 1;173(4):371-378.
2018
Kong L, Norstedt G, Schalling M, Gissler M, Lavebratt C. The Risk of Offspring Psychiatric Disorders in the Setting of Maternal Obesity and Diabetes. Pediatrics 2018; 142(3):e20180776.
Bateman BT, Heide-Jørgensen U, Einarsdóttir K, Engeland A, Furu K, Gissler M, Hernandez-Diaz S, Kieler H, Lahesmaa-Korpinen AM, Mogun H, Nørgaard M, Reutfors J, Selmer R, Huybrechts KF, Zoega H.β-Blocker Use in Pregnancy and the Risk for Congenital Malformations: An International Cohort Study. Ann Intern Med. 2018 Nov 20; 169(10):665-673.
Kemppainen M, Lahesmaa-Korpinen AM, Kauppi P, Virtanen M, Virtanen SM, Karikoski R, Gissler M, Kirjavainen T. Maternal asthma is associated with increased risk of perinatal mortality. PLoS One. 2018 May 18; 13(5):e0197593.
2013-2017
Furu K, Kieler H, Haglund B, Engeland A, Selmer R, Stephansson O, Valdimarsdottir UA, Zoega H, Artama M, Gissler M, Malm H, Nørgaard M. Selective Serotonin-Reuptake Inhibitors and Venlafaxine in early pregnancy and risk of birth defects – a population based cohort study and sibling design. BMJ 2015 Apr 17;350:h1798.
Kieler H, Malm H, Artama M, Engeland A, Furu K, Gissler M, Nørgaard M, Stephansson O, Valdimarsdottir U, Zoega H, Haglund B. Use of antidepressants and association with elective termination of pregnancy: population based case-control study. BJOG 2015 Nov;122(12):1618-24.
Artama M, Malm H, Ritvanen A, Gissler M. Effects of maternal epilepsy and antiepileptic drug use during pregnancy on perinatal health in offspring- nationwide, retrospective cohort study in Finland. Drug Safety 2013; 36: 359–369.
Stephansson O, Kieler H, Haglund B, Artama M, Engeland A, Furu K, Gissler M, Nørgaard M, Nielsen RB, Zoega H, Valdimarsdóttir U. Selective serotonin reuptake inhibitors during pregnancy and risk of stillbirth and infant mortality. JAMA 2013; 309(1):48−54.
2008-2012
Kieler H, Artama M, Engeland A, Ericsson O, Furu K, Gissler M, Nielsen RB, Nørgaard M, Stephansson O, Valdimarsdottir U, Zoega H, Haglund B. Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries. BMJ 2012; 344:d8012.
Malm H, Artama M, Brown AS, Gissler M, Gyllenberg D, Hinkka-Yli-Salomäki S, McKeague I, Sourander A. Infant and childhood neurodevelopmental outcomes following prenatal exposure to selective serotonin reuptake inhibitors: overview and design of a Finnish Register-Based Study (FinESSI). BMC Psychiatry 2012; 12:217.
Malm H, Artama M, Gissler M, Ritvanen A. Selective serotonin reuptake inhibitors and risk for major congenital anomalies. Obstet Gynecol 2011; 118(1):111−20.
Artama M, Gissler M, Malm H, Ritvanen A, Drugs and Pregnancy Study Group. Nationwide register-based surveillance system on drugs and pregnancy in Finland 1996-2006. Pharmacoepidemiol Drug Saf 2011; 20(7):729−38.
Gissler M, Artama M, Ritvanen A, Wahlbeck K. Use of psychotropic drugs before pregnancy and the risk for induced abortion: population-based register-data from Finland 1996-2006. BMC Public Health 2010; 10:383.
Hankeraportit
Leinonen, Maarit ym. (2022) Raskausajan lääkkeiden käyttö ja syntyneiden lasten terveys 1996–2019. Raportti 13/2022. Helsinki: Terveyden ja hyvinvoinnin laitos.
Leinonen, Maarit ym. (2020) Raskausajan lääkkeiden käyttö ja syntyneiden lasten terveys 1996–2016. Raportti 16/2020. Helsinki: Terveyden ja hyvinvoinnin laitos.
Lahesmaa-Korpinen, Anna-Maria ym. (2014) Raskaudenaikainen lääkkeidenkäyttö, syntyneiden lasten perinataaliterveys sekä epämuodostumat 1996-2010. Raportti 20/2014. Helsinki: Terveyden ja hyvinvoinnin laitos.
Artama, Miia ym. (2009) Lääke ja raskaus pilottihankkeen tuloksia: raskauden aikainen lääkkeiden käyttö, syntyneiden lasten perinataaliterveys ja epämuodostumariski. Raportti 28/2009. Helsinki: Terveyden ja hyvinvoinnin laitos.
